Das Knochenmark des erwachsenen Schädels ist ein expandierendes und widerstandsfähiges hämatopoetisches Reservoir

https://www.nature.com/articles/s41586-024-08163-9

4 Comments

  1. towngrizzlytown on

    >During ageing, bone marrow in the skull becomes an increasingly important site of blood-cell production. This is in stark contrast to most bones where the ability of marrow to make blood and immune cells declines. Studies in mice and humans showed that ageing results in skull bone-marrow expanding, and in mice this marrow was more resistant to inflammation and other hallmarks of ageing. The team behind the work hope by understanding this process better it may be possible to help organs become more resistant to ageing.

  2. 72Pantagruel on

    Awesome read.
    We did transplant experiments in sub-lethal irradiated mice some 10 years ago (CML ‘stem cells’) but never checked the skull marrow for homing of/repopulation with the human stem cells. We did find them in the BM and spleen.
    A small captain hindsight moment.

  3. EarnestAsshole on

    Seeing the bone marrow thickening in aging skulls kind of reminds me of the “chipmunk facies” we sometimes see in individuals affected by Beta Thalassemia, where ineffective erythropoiesis causes bone marrow expansion in areas like the skull.

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