Forscher haben identifiziert, dass der TrkC-PTPσ-Proteinkomplex für die Kommunikation zwischen Gehirnzellen von entscheidender Bedeutung ist und angstbezogenes Verhalten beeinflusst. Die Störung der it-Mäuse führte zu einer abnormalen Synapsenorganisation und Angstzuständen und bot potenzielle neue therapeutische Angriffspunkte für Angstzustände, Autismus und Schizophrenie

>Takahashi’s team has previously discovered a new protein complex within the synaptic junction, called TrkC-PTPσ, which is only found in excitatory synapses. The genes coding for TrkC (NTRK3) and PTPσ (PTPRS) are associated with anxiety disorders and autism, respectively. However, the mechanisms by which this complex regulates synapse development and contributes to cognitive functions are unknown.
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>The work carried out in the new study by first author Husam Khaled, a doctoral student in Takahashi’s laboratory, showed that the TrkC-PTPσ complex regulates the structural and functional maturation of excitatory synapses by regulating the phosphorylation, a biochemical protein modification, of many synaptic proteins, while disruption of this complex causes specific behavioral defects in mice.
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Paper: [The TrkC-PTPσ complex governs synapse maturation and anxiogenic avoidance via synaptic protein phosphorylation | The EMBO Journal](https://www.embopress.org/doi/full/10.1038/s44318-024-00252-9)