Studie unterstützt neuen blutbasierten Biomarker zur Erkennung früher Gehirnveränderungen, die zu kognitiven Beeinträchtigungen und Demenz führen

>The researchers studied possible associations involving several factors: plasma levels of PlGF, a highly sensitive research MRI measure of fluid accumulation in the brain called white matter free water (FW), white matter hyperintensities, and patients’ scores on cognitive assessments. Results were consistent with models suggesting that elevated PlGF increases vascular permeability, leading to accumulation of fluid in the brain’s white matter, development of white matter hyperintensities and subsequent cognitive impairment.

Paper: [White matter free water mediates the associations between placental growth factor, white matter hyperintensities, and cognitive status – Kern – Alzheimer’s & Dementia – Wiley Online Library](https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.14408)