**Biological brain age and resilience in cognitively unimpaired 70-year-old individuals**
Abstract
INTRODUCTION
This study investigated the associations of brain age gap (BAG)—a biological marker of brain resilience—with life exposures, neuroimaging measures, biological processes, and cognitive function.
METHODS
We derived BAG by subtracting predicted brain age from chronological age in 739 septuagenarians without dementia or neurological disorders. Robust linear regression models assessed BAG associations with life exposures, plasma inflammatory and metabolic biomarkers, magnetic resonance imaging, and cerebrospinal fluid biomarkers of neurodegeneration and vascular brain injury, and cognitive performance.
RESULTS
Greater BAG (older-looking brains) was associated with physical inactivity, diabetes, and stroke, while prediabetes was related to lower BAG, that is, younger-looking brains. Physical activity mitigated the link between obesity and BAG. Greater BAG was associated with greater small vessel disease burden, white-matter alterations, inflammation, high glucose, poorer vascular-related cognitive domains. Sex-specific associations were identified.
DISCUSSION
Vascular-related lifestyles and health shape brain appearance. Inflammation and insulin-related processes may be keys to understanding vascular cognitive disorders.
Supppose that’s why they call it Vascular Dimentia.
InTheEndEntropyWins on
Poor vascular health of the brain is linked to various mental health issues, like depression and dementia.
It might be partly the mechanism why exercise which improves the vascular health of the brain is the most effective thing you can do for depression or dementia.
>For the AD portrait, the top three scoring treatments for reversing AD expression with little effect on exacerbating AD expression were for exercise. [https://www.nature.com/articles/s41598-022-22179-z#Sec2](https://www.nature.com/articles/s41598-022-22179-z#Sec2)
.
>University of South Australia researchers are calling for exercise to be a mainstay approach for managing depression as a new study shows that physical activity is 1.5 times more effective than counselling or the leading medications. [https://www.unisa.edu.au/media-centre/Releases/2023/exercise-more-effective-than-medicines-to-manage-mental-health](https://www.unisa.edu.au/media-centre/Releases/2023/exercise-more-effective-than-medicines-to-manage-mental-health)
So remember if you want your brain to be in good biological health you need to exercise, have a good diet and sleep well.
considertheoctopus on
“Surely the mind hardens as fast as the arteries… trust no thought arrived at sitting down.
Ab47203 on
Let me guess. The way to keep yourself healthy is expensive?
melissqua on
But no one will take their statin because of that one study saying it will cause dementia!
Plow_King on
how does one assess “vascular health”? that’s a real question, for me at least.
7 Comments
**Biological brain age and resilience in cognitively unimpaired 70-year-old individuals**
Abstract
INTRODUCTION
This study investigated the associations of brain age gap (BAG)—a biological marker of brain resilience—with life exposures, neuroimaging measures, biological processes, and cognitive function.
METHODS
We derived BAG by subtracting predicted brain age from chronological age in 739 septuagenarians without dementia or neurological disorders. Robust linear regression models assessed BAG associations with life exposures, plasma inflammatory and metabolic biomarkers, magnetic resonance imaging, and cerebrospinal fluid biomarkers of neurodegeneration and vascular brain injury, and cognitive performance.
RESULTS
Greater BAG (older-looking brains) was associated with physical inactivity, diabetes, and stroke, while prediabetes was related to lower BAG, that is, younger-looking brains. Physical activity mitigated the link between obesity and BAG. Greater BAG was associated with greater small vessel disease burden, white-matter alterations, inflammation, high glucose, poorer vascular-related cognitive domains. Sex-specific associations were identified.
DISCUSSION
Vascular-related lifestyles and health shape brain appearance. Inflammation and insulin-related processes may be keys to understanding vascular cognitive disorders.
[https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.14435](https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.14435)
Supppose that’s why they call it Vascular Dimentia.
Poor vascular health of the brain is linked to various mental health issues, like depression and dementia.
It might be partly the mechanism why exercise which improves the vascular health of the brain is the most effective thing you can do for depression or dementia.
>For the AD portrait, the top three scoring treatments for reversing AD expression with little effect on exacerbating AD expression were for exercise. [https://www.nature.com/articles/s41598-022-22179-z#Sec2](https://www.nature.com/articles/s41598-022-22179-z#Sec2)
.
>University of South Australia researchers are calling for exercise to be a mainstay approach for managing depression as a new study shows that physical activity is 1.5 times more effective than counselling or the leading medications. [https://www.unisa.edu.au/media-centre/Releases/2023/exercise-more-effective-than-medicines-to-manage-mental-health](https://www.unisa.edu.au/media-centre/Releases/2023/exercise-more-effective-than-medicines-to-manage-mental-health)
So remember if you want your brain to be in good biological health you need to exercise, have a good diet and sleep well.
“Surely the mind hardens as fast as the arteries… trust no thought arrived at sitting down.
Let me guess. The way to keep yourself healthy is expensive?
But no one will take their statin because of that one study saying it will cause dementia!
how does one assess “vascular health”? that’s a real question, for me at least.