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    Ein Antidepressivum könnte bei der Behandlung von Kindern und Jugendlichen mit ADHS helfen – eine neue Studie ergab, dass Viloxazin besser wirkte als Placebo, gut verträglich war und eine nützliche nicht-stimulierende Behandlung für ADHS sein könnte, wobei die beste Dosis 200–400 mg beträgt.


    Ein Antidepressivum könnte bei der Behandlung von Kindern und Jugendlichen mit ADHS helfen – eine neue Studie ergab, dass Viloxazin besser wirkte als Placebo, gut verträglich war und eine nützliche nicht-stimulierende Behandlung für ADHS sein könnte, wobei die beste Dosis 200–400 mg beträgt.

    https://www.scimex.org/newsfeed/an-antidepressant-could-help-treat-kids-and-teen-with-adhd

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    6 Comments

    1. mvea on

      I’ve linked to the news release in the post above. In this comment, for those interested, here’s the link to the peer reviewed journal article:

      https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2826361

      Key Points

      Question Is viloxazine associated with effective and acceptable outcomes among children and adolescents with attention-deficit/hyperactivity disorder (ADHD), and how are these outcomes associated with dose and treatment duration?

      Findings In this meta-analysis that included 5 fixed-dose randomized clinical trials and 1560 participants, viloxazine was associated with better efficacy in treating ADHD symptoms compared with placebo, showing bell-shaped response trajectories.

      Meaning In this study, viloxazine was well-tolerated and associated with improvements in ADHD symptoms, and a moderate dose (200-400 mg or 6-8 mg/kg) appeared to provide the best treatment outcomes.

      From the linked article:

      The antidepressant viloxazine may be an effective treatment for kids and teens with ADHD, according to international research which found it worked better than placebo and was relatively well tolerated. The study, which pooled together previous research, found that the drug could be a useful non-stimulant treatment for ADHD and the best dose was 200-400mg. The authors say head-to-head studies are still needed to compare the efficacy of viloxazine with other ADHD medications.

    2. PotsAndPandas on

      A shame this isn’t more long term. One of the most interesting features of stimulant medication is the long term, positive effects on the brains of ADHD patients. The idea that we can create long term, positive effects with stimulants, then manage any remaining symptoms by moving treatment to non-stimulant medication could be an incredible combination.

    5. grat_is_not_nice on

      I was on a SSRI (sertraline) for several years. I have recently switched to bupropion, which is a DNRI (dopamine and norepinephrine reuptake Inhibitor). The difference to my focus/attention is startling. I hadn’t sought treatment for my ADHD (because I am an old man), but bupropion is fantastic. So I can see how viloxazine might be a good choice.

    6. TAU_equals_2PI on

      Not a chance. This medication has been around for 50 years. The idea that somehow it’s very effective for ADHD but that has escaped notice all this time despite being in widespread use for other purposes is just absurd.

      It’s a sad indictment of the progress in this area that the most effective current medications were developed something like 70 years ago, and no serious progress has been made since then. Just extended-release formats of the same old Ritalin and amphetamines.

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