Die langfristige Einnahme von blutdrucksenkenden, cholesterinsenkenden, harntreibenden und blutverdünnenden Medikamenten ist mit einem um 4 bis 25 % verringerten Demenzrisiko verbunden. Die Kombination dieser Medikamente bietet eine stärkere Schutzwirkung als die Einzelanwendung

>The researchers used Swedish national registers. Around 88,000 people over the age of 70 who were diagnosed with dementia between 2011 and 2016 were included in the study, as well as 880,000 controls. Information on cardiovascular medicines was obtained from the Swedish Prescribed Drug Register. 
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>The results show that long-term use of antihypertensive drugs, cholesterol-lowering drugs, diuretics and blood-thinning drugs is associated with between 4 and 25 per cent lower risk of dementia. Combinations of the drugs had stronger protective effects than if they were used alone. 

>**Some drugs linked to higher risk**
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>The researchers also found that, on the contrary, the use of antiplatelet drugs may be linked to a higher risk of dementia. Antiplatelet drugs are medicines used to prevent strokes and stop platelets from clumping together. One possible explanation is that these drugs increase the risk of microbleeds in the brain, which are associated with cognitive decline.  

Paper: [Use of common cardiovascular disease drugs and risk of dementia: A case–control study in Swedish national register data – Ding – Alzheimer’s & Dementia – Wiley Online Library](https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.14389)