Erste Studie, die zeigt, dass der Konsum von hochwirksamem Cannabis deutliche Spuren in der DNA hinterlässt und wertvolle Einblicke in die biologischen Auswirkungen des Cannabiskonsums liefert.
First study to show high potency cannabis use leaves unique signature on DNA
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From the article: High potency cannabis use leaves a distinct mark on DNA, according to [new research](https://www.kcl.ac.uk/news/first-study-to-show-high-potency-cannabis-use-leaves-unique-signature-on-dna) by the Institute of Psychiatry, Psychology & Neuroscience at King’s College London and the University of Exeter.
Published in Molecular Psychiatry, this is the first study to suggest that the use of high potency cannabis (defined as having THC content of 10 per cent or greater) leaves a distinct mark on DNA, providing valuable insights into the biological impact of cannabis use.
The research also showed the effect of cannabis use on DNA is different in people experiencing their first episode of psychosis compared to users who have never experienced psychosis, suggesting there could be potential for DNA blood tests to help characterise those cannabis users at risk of developing psychosis to inform preventative approaches.
The study was funded by the Medical Research Centre, the National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre (BRC) and the NIHR Exeter BRC.
Senior author Marta Di Forti, Professor of Drugs, Genes and Psychosis at King’s IoPPN said: “With the increasing prevalence of cannabis use and more availability of high potency cannabis, there is a pressing need to better understand its biological impact, particularly on mental health. Our study is the first to show high potency cannabis leaves a unique signature on DNA related to mechanisms around the immune system and energy production.
“Future research needs to explore if the DNA signature for current cannabis use, and in particular the one of high potency types, can help identify those users most at risk to develop psychosis, both in recreational and medicinal use settings.”
It would be good to have a test available that can tell you if cannabis is going to mix poorly with your system. It definitely affects different people in different ways.
Wait till they see what high doses of alcohol and tobacco do to you!
Whooooooaa…….. ONE WITH THE TREE!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
I wonder if regular usage also affects the body’s reaction to medicine, if it amplifies or minimizes the efficacy requiring higher dosages?
Can’t wait to learn what I’ve been doing to myself all these years
10% or higher THC seems like a low bar for “high potency.”
Quite an interesting original paper but it is just one small step forward in knowledge. There are no firm conclusions. I also am disappointed that the study uses illegally bought street cannabis – some of which is likely to be synthetics. That adds a lot of uncertainty to any potential conclusions.