Weniger essen kann zu einem längeren Leben führen: Eine umfangreiche Studie an Mäusen zeigt, warum. Gewichtsverlust und Stoffwechselverbesserungen erklären nicht die Vorteile der Langlebigkeit. Immungesundheit, Genetik und physiologische Indikatoren der Widerstandsfähigkeit scheinen den Zusammenhang zwischen Kalorienreduzierung und längerer Lebensdauer besser zu erklären.

I’ve linked to the news release in the post above. In this comment, for those interested, here’s the link to the peer reviewed journal article:

https://www.nature.com/articles/s41586-024-08026-3

From the linked article:

Eating less can lead to a longer life: massive study in mice shows why

Weight loss and metabolic improvements do not explain the longevity benefits of severe dietary restrictions.

Cutting calorie intake can lead to a leaner body — and a longer life, an effect often chalked up to the weight loss and metabolic changes caused by consuming less food. Now, one of the biggest studies1 of dietary restrictions ever conducted in laboratory animals challenges the conventional wisdom about how dietary restriction boosts longevity.

The study, involving nearly 1,000 mice fed low-calorie diets or subjected to regular bouts of fasting, found that such regimens do indeed cause weight loss and related metabolic changes. But other factors — including immune health, genetics and physiological indicators of resiliency — seem to better explain the link between cutting calories and increased lifespan.

“The metabolic changes are important,” says Gary Churchill, a mouse geneticist at the Jackson Laboratory in Bar Harbor, Maine, who co-led the study. “But they don’t lead to lifespan extension.”