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    Personen, die als Kinder mehr Widrigkeiten erlebt haben, reagieren weniger auf Methamphetamin.

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    7 Comments

    1. mvea on

      I’ve linked to the news release in the post above. In this comment, for those interested, here’s the link to the peer reviewed journal article:

      https://journals.sagepub.com/doi/10.1177/02698811241268892

      From the linked article:

      An analysis of data from several previous studies indicated that individuals who experienced more childhood adversity tend to show dampened subjective responses to methamphetamine and d-amphetamine 90 to 180 minutes after administration. However, their subjective responses to buprenorphine were not affected, and this drug had little overall effect on the participants. The research was published in the Journal of Psychopharmacology.

      The results showed that participants reporting higher levels of childhood adversity tended to report lower subjective effects of methamphetamine and d-amphetamine. These individuals reported feeling the drug effects less intensely, liking them less, and experiencing a lower drug-induced high. However, the degree to which participants disliked the drug or wanted more of it was not associated with reported childhood adversity.

      Buprenorphine had little effect on participants overall. The effects of the dose used in the study were indistinguishable from placebo (when participants received a pill they believed contained the drug, but it did not). These effects, or the lack thereof, were not associated with reported childhood adversity.

    2. Sol_Freeman on

      Very interesting. I wonder if adversity affects other drugs like marijuana, heroin, or cocaine.

    4. The_Singularious on

      I wonder if this can be extrapolated out to ADHDers who had adverse childhoods seeing less effect from Adderall, or requiring larger doses for effectiveness.

    7. Durant-Wolgast12 on

      People need to exercise critical thinking instead of taking these worthless studies at face value.

      * A laughably small 10% of the sample reported adversity in childhood.
      * Small sample being surveyed on their **subjective** responses to amphetamine.
      * It excludes those with substance abuse, who are the people of most interest since they would likely have faced the greatest adversity during childhood.

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